leukotriene c4 การใช้

• In 1997 he received first prize of " The Lancet " for the paper reporting on genetic polymorphism of leukotriene C4 syntase.
• This formation of hepoxilin A3-C appears analogous to the formation of leukotriene C4 by the conjugation of glutathione to leukotriene A4.
• However, their production is stimulated in human eosinophils by physiological agonists such as prostaglandin D2, leukotriene C4, and interleukin 5.
• A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein.
• The protein encoded by this gene, LTC4S ( or "'glutathione S-transferase II "') is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4.
• Included are the 5-lipoxygenase-activating protein ( gene FLAP ), leukotriene C4 synthase ( ), which catalyzes the production of leukotriene C4 ( LTC4 ) from leukotriene A4 ( LTA4 ), and microsomal glutathione S-transferase II ( ) ( GST-II ), which also produces LTC4 from LTA4.
• Included are the 5-lipoxygenase-activating protein ( gene FLAP ), leukotriene C4 synthase ( ), which catalyzes the production of leukotriene C4 ( LTC4 ) from leukotriene A4 ( LTA4 ), and microsomal glutathione S-transferase II ( ) ( GST-II ), which also produces LTC4 from LTA4.
• 5-( " S " )-HETE family members share a common receptor target for stimulating cells that differs from and receptors targeted by the other major products of ALOX5, i . e ., leukotriene B4, leukotriene C4, leukotriene D4, leukotriene E4, lipoxin A4, and lipoxin B4; members of the 5-( " S " )-HETE family stimulate cells primarily by binding and thereby activating a dedicated G protein-coupled receptor, the oxoeicosanoid receptor 1 or OXER1 ( also termed OXE, OXE-R, hGPCR48, HGPCR48, or R527 receptor ); OXER1's gene is sometimes termed OXE1.